Radioiodinated esomeprazole as a model for peptic ulcer localization-Reference-Cited by-同舟云学术

Radioiodinated esomeprazole as a model for peptic ulcer localization

Published:2021-07-27 Issue:9 Volume:109 Page:711-718
ISSN:0033-8230
Container-title:Radiochimica Acta
language:en
Short-container-title:

Author:

Sanad M. H.¹,Eyssa H. M.²,Gomaa N. M.³,Marzook F. A.¹,Bassem S. A.⁴

Affiliation:

1. Labeled Compounds Department , Hot Labs Center, Egyptian Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt

2. Radiation Chemistry Department , National Center for Research and Radiation Technology, Egyptian Atomic Energy Authority , P.O. Box 29 , Cairo , Egypt

3. Radiation Microbiology Department/Biotechnology/National Center for Research and Radiation Technology , Egyptian Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt

4. Food Toxicology and Contaminants Department , National Research Centre , Dokki , Cairo , Egypt

Abstract

Abstract This work focuses on tracking stomach ulcer localized in mice. High labeling yield and radiochemical purity were achieved for the formation of a [125I]esomeprazole radiotracer at optimum conditions of oxidizing agent content (chloramines-T (Ch-T), 100 μg), substrate amount (Esom, 100 μg), pH of reaction mixture (6), reaction time (30 min) and temperature (37 °C), using radioactive iodine-125 (200–450 MBq). The radiolabeled compound, [125I]esom, was stable in serum and saline solution during 24 h. Esom is acting as a histamine-2-receptor antagonist (H2RA). Biodistribution studies were carried in normal and ulcerated mice. High uptake of 78.12 ± 0.80% injected dose/g organ (ID/g) observed in ulcerated mice confirmed the suitability of [125I]esomeprazole as a novel radiotracer for stomach imaging.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/ract-2021-1056/pdf

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