125I–Amoxicillin preparation as a guide tracer for inflammation detection-Reference-Cited by-同舟云学术

125I–Amoxicillin preparation as a guide tracer for inflammation detection

Published:2021-08-23 Issue:10 Volume:109 Page:773-779
ISSN:0033-8230
Container-title:Radiochimica Acta
language:en
Short-container-title:

Author:

El Refaye Marwa S.¹²,El-Sharawy Dina M.²³⁴,Hussien Heba²³

Affiliation:

1. Radioactive Isotopes and Generators Department , Hot Laboratory Center, Egyptian Atomic Energy Authority (EAEA) , P.O. Box 13759 , Cairo , Egypt

2. Cyclotron Project, Nuclear Research Centre, Egyptian Atomic Energy Authority (EAEA) , P.O. Box 13759 , Cairo , Egypt

3. Labeled Compounds Department , Hot Laboratory Center, Egyptian Atomic Energy Authority (EAEA) , P.O. Box 13759 , Cairo , Egypt

4. Pharmaceutics and Clinical Pharmacy Department , Faculty of Pharmacy, Nahda University , Beni Suef , Egypt

Abstract

Abstract The objective of this study is to label Amoxicillin with radioactive iodine (125I-AC) via direct electrophilic substitution to act as a promising tracer for inflammation imaging. The highest labeling yield of 80% was achieved after studying all the parameters affecting the labeling reaction using Iodogen (IG) as an oxidizing agent. Molecular Modeling Structure was done using MOE program to predict the suitable 125I position. The product structure was established by a cold iodination reaction using Iodine-127. Biological evaluation of (125I-AC) was carried out using groups of inflamed mice with different exogenous agents such as E.Coli and Turpentine oil. The (125I-AC) shows an in vitro stability of about 97% after 24 h.While doing in vivo studies over 4 h, the tracer stability of 99% was observed.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/ract-2021-1077/pdf

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