Reference ranges for sphingosine-1-phosphate in neonates-Reference-Cited by-同舟云学术

Reference ranges for sphingosine-1-phosphate in neonates

Published:2021-04-15 Issue:7 Volume:49 Page:932-935
ISSN:0300-5577
Container-title:Journal of Perinatal Medicine
language:en
Short-container-title:

Author:

Ebenebe Chinedu Ulrich¹,von Lucadou Mirjam²,Moritz Eileen³,Schwedhelm Edzard²,Daum Guenter⁴,Singer Dominique¹,Deindl Phillip¹,Winkler Martin Sebastian⁵

Affiliation:

1. Department of Pediatrics , Division of Neonatology and Pediatric Intensive Care, University Medical Center Hamburg-Eppendorf , Hamburg , Germany

2. Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf , Hamburg , Germany

3. Department of General Pharmacology , Institute of Pharmacology, University Medicine , Greifswald , Germany

4. Department of Vascular Medicine , University Heart and Vascular Center Hamburg-Eppendorf , Hamburg , Germany

5. Department of Anesthesiology , University Medical Center Goettingen , Goettingen , Germany

Abstract

Abstract Objectives Sphingosine-1-phosphate (S1P) is a signalling lipid involved in embryonic development, physiological homeostasis, and pathogenic processes in multiple organ systems. Disturbance of S1P homeostasis has been associated with various human diseases in which the immune response and vascular integrity are severely compromised. Up-to-date, no study has analyzed S1P levels in neonates. The objective of this study was to determine S1P serum concentrations in neonates and establish S1P reference ranges. Methods S1P levels in the umbilical cord blood of 460 term and preterm neonates were compared to a previously described cohort of healthy adult blood donors. S1P levels were further correlated with demographic characteristics, cellular sources of S1P, and inflammatory markers. Results The median S1P serum level in neonates was 1.70 μmol/L (IQR 1.41–1.97 μmol/L) and significantly higher than normal values reported in adults. S1P levels correlated positively with the number of red blood cells (p<0.001) and negatively with neutrophil precursors (p=0.028). Conclusions Elevated S1P levels in neonates compared to adults possibly result from higher S1P content in its cellular sources due to the essential role of S1P during embryogenesis. Generated S1P ranges may be used as reference ranges for future studies in neonates.

Publisher

Walter de Gruyter GmbH

Subject

Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health

Link

https://www.degruyter.com/document/doi/10.1515/jpm-2020-0536/pdf

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