Liver cell hydration and integrin signaling-Reference-Cited by-同舟云学术

Liver cell hydration and integrin signaling

Published:2021-04-29 Issue:9 Volume:402 Page:1033-1045
ISSN:1431-6730
Container-title:Biological Chemistry
language:en
Short-container-title:

Author:

Bonus Michele¹^ORCID,Häussinger Dieter²,Gohlke Holger¹³⁴^ORCID

Affiliation:

1. Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf , Universitätsstr. 1 , D-40225 Düsseldorf , Germany

2. Clinic for Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Düsseldorf , Moorenstr. 5 , D-40225 Düsseldorf , Germany

3. John von Neumann Institute for Computing (NIC), Jülich Supercomputing Centre (JSC) , Wilhelm-Johnen-Str. , D-52428 Jülich , Germany

4. Institute of Biological Information Processing (IBI-7: Structural Biochemistry), and Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich GmbH , Wilhelm-Johnen-Str. , D-52428 Jülich , Germany

Abstract

Abstract Liver cell hydration (cell volume) is dynamic and can change within minutes under the influence of hormones, nutrients, and oxidative stress. Such volume changes were identified as a novel and important modulator of cell function. It provides an early example for the interaction between a physical parameter (cell volume) on the one hand and metabolism, transport, and gene expression on the other. Such events involve mechanotransduction (osmosensing) which triggers signaling cascades towards liver function (osmosignaling). This article reviews our own work on this topic with emphasis on the role of β1 integrins as (osmo-)mechanosensors in the liver, but also on their role in bile acid signaling.

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/hsz-2021-0193/pdf

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