Treatment of gastric cancer by green mediated silver nanoparticles using <i>Pistacia atlantica</i> bark aqueous extract-Reference-Cited by-同舟云学术

Treatment of gastric cancer by green mediated silver nanoparticles using Pistacia atlantica bark aqueous extract

Published:2023-01-01 Issue:1 Volume:21 Page:
ISSN:2391-5420
Container-title:Open Chemistry
language:en
Short-container-title:

Author:

Dang Ling¹,Yang Jian²,Negm Sally³,El-kott Attalla F.⁴⁵,Shati Ali A.⁴,Ghamry Heba I.⁶,Karmakar Bikash⁷

Affiliation:

1. Department of Surgery, Baishui Hospital of Traditional Chinese Medicine , Weinan , 719000 , China

2. Characteristic Medical Center of Chinese People’s Armed Police Force , Tianjin , 300162 , China

3. Department of Life Sciences, College of Science and Art Mahyel Aseer, King Khalid University , Abha 62529 , Saudi Arabia

4. Department of Biology, College of Science, King Khalid University , Abha 61421 , Saudi Arabia

5. Department of Zoology, Faculty of Science, Damanhour University , Damanhour , 22511 , Egypt

6. Department of Home Economics, Faculty of Home Economics, King Khalid University , P.O. Box 960 , Abha, 61421 , Saudi Arabia

7. Department of Chemistry, Gobardanga Hindu College , 24-Parganas (North) , Gobardanga , India

Abstract

Abstract We herein demonstrate a novel green mediated silver nanoparticles (AgNPs) using Pistacia atlantica bark aqueous extract for the treatment of gastric cancer under in vitro conditions. Physicochemical and structural features of the nanocomposite biomaterial were assessed by several techniques like UV-Vis spectrum, transmission electron spectroscopy, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, and inductively coupled plasma-optical emission spectroscopy. The Ag NPs showed high antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl (DPPH). The IC50 of Ag NPs and Butylated hydroxytoluene against DPPH were 132 and 77 µg/mL, respectively. In the oncological part of this research, the status of normal and gastric cancer AGS and KATO III cell lines was determined. The IC50 of AgNPs was 193 and 250 µg/mL against AGS and KATO III. It seems that the prepared NP have stopped the growth of gastric cancer cells and the recent cancer cells have been removed with high concentration of NPs.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/chem-2023-0157/pdf

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