Structural study of anhydrous and hydrated 5-fluorouracil co-crystals with nicotinamide and isonicotinamide
Author:
Heinen Tobias1, Hoelscher Sandra1, Vasylyeva Vera1
Affiliation:
1. Department of Inorganic and Structural Chemistry I , Heinrich-Heine University Duesseldorf , Universitaetsstr. 1 , 40225 Duesseldorf , Germany
Abstract
Abstract
5-Fluorouracil is a widely used anti-cancer drug which exhibits diverse polymorphic and co-crystalline behavior. Here we report two new solvent-free co-crystals of 5-fluorouracil with model co-formers nicotinamide and isonicotinamide, along with the redetermination of their hydrated analogues. Selected co-formers are categorized as safe and therefore suitable for pharmaceutical applications. Differences and similarities in supramolecular topology of the given structures are discussed. A special emphasis is set on the influence of fluorine moieties on the overall packing and synthetic accessibility of the presented multi-component systems.
Publisher
Walter de Gruyter GmbH
Subject
Inorganic Chemistry,Condensed Matter Physics,General Materials Science
Reference25 articles.
1. Vincent, M., Labianca, R., Harper, P. Anti Cancer Drugs 1999, 10, 337–354; https://doi.org/10.1097/00001813-199904000-00001. 2. Peled, Y., Levavi, H., Krissi, H., Weill, Y., Sabah, G., Eitan, R. Am. J. Clin. Oncol. 2013, 36, 472–474; https://doi.org/10.1097/coc.0b013e3182549399. 3. Shapiro, L. Q., Sherman, E. J., Riaz, N., Setton, J., Koutcher, L., Zhang, Z., Shi, W., Fury, M. G., Wolden, S. L., Pfister, D. G., Morris, L., Lee, N. Oral Oncol. 2014, 50, 947–955; https://doi.org/10.1016/j.oraloncology.2014.07.001. 4. Qu, C.-Y., Zhou, M., Chen, Y.-W., Chen, M.-M., Shen, F., Xu, L.-M. Int. J. Nanomed. 2015, 10, 3911–3920. 5. Diasio, R. B., Harris, B. E. Clin. Pharmacokinet. 1989, 16, 215–237; https://doi.org/10.2165/00003088-198916040-00002.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|