New lipophilic organic nitrates: candidates for chronic skin disease therapy
Author:
Marini Elisabetta1, Sodano Federica2, Rolando Barbara1, Chegaev Konstantin1, Maresca Daniela Claudia2, Ianaro Angela2, Ercolano Giuseppe2, Lazzarato Loretta1
Affiliation:
1. Department of Drug Science and Technology , University of Turin , I-10125 Turin , Italy 2. Department of Pharmacy , University of Naples «Federico II» , I-80131 Naples , Italy
Abstract
Abstract
Organic nitrates are widely used, but their chronic efficacy is blunted due to the development of tolerance. The properties of new tolerance free organic nitrates were studied. Their lipophilicity profile and passive diffusion across polydimethylsiloxane membrane and pig ear-skin, and their efficacy in tissue regeneration using HaCaT keratinocytes were evaluated. The permeation results show that these nitrates have a suitable profile for NO topical administration on the skin. Furthermore, the derivatives with higher NO release exerted a pro-healing effect on HaCaT cells. This new class of organic nitrates might be a promising strategy for the chronic treatment of skin pathologies.
Publisher
Walter de Gruyter GmbH
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
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