Assessment of the breadth of binding promiscuity of heme towards human proteins-Reference-Cited by-同舟云学术

Assessment of the breadth of binding promiscuity of heme towards human proteins

Published:2022-10-18 Issue:11-12 Volume:403 Page:1083-1090
ISSN:1431-6730
Container-title:Biological Chemistry
language:en
Short-container-title:

Author:

Roumenina Lubka T.¹,Dimitrov Jordan D.¹^ORCID

Affiliation:

1. Centre de Recherche des Cordeliers, INSERM, CNRS, Sorbonne Université, Université de Paris , Centre de Recherche des Cordeliers 15, rue de l’Ecole de Médecine, F-75006 Paris , France

Abstract

Abstract Heme regulates important biological processes by transient interactions with many human proteins. The goal of the present study was to assess extends of protein binding promiscuity of heme. To this end we evaluated interaction of heme with >9000 human proteins. Heme manifested high binding promiscuity by binding to most of the proteins in the array. Nevertheless, some proteins have outstanding heme binding capacity. Bioinformatics analyses revealed that apart from typical haemoproteins, these proteins are frequently involved in metal binding or have the potential to recognize DNA. This study can contribute for understanding the regulatory functions of labile heme.

Funder

European Research Council

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/hsz-2022-0226/pdf

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