The effects of pioglitazone and rosiglitazone on liver function in hypothyroid rats

Author:

Baghcheghi Yousef12,Beheshti Farimah34,Seyedi Fatemeh5,Hedayati-Moghadam Mahdiyeh26ORCID,Askarpour Hedyeh2,Kheirkhah Aliasghar7,Golkar Ahmad2,Dalfardi Mohammad2,Hosseini Mahmoud8910

Affiliation:

1. Bio Environmental Health Hazards Research Center , Jiroft University of Medical Sciences , Jiroft , Iran

2. Student Research Committee , Jiroft University of Medical Sciences , Jiroft , Iran

3. Neuroscience Research Center , Torbat Heydariyeh University of Medical Sciences , Torbat Heydariyeh , Iran

4. Department of Physiology, School of Medicine , Torbat Heydariyeh University of Medical Sciences , Torbat Heydariyeh , Iran

5. Department of Anatomical Sciences, School of Medicine , Jiroft University of Medical Sciences , Jiroft , Iran

6. Department of Physiology, School of Medicine , Jiroft University of Medical Sciences , Jiroft , Iran

7. Clinical Research Development Center of Imam Khomeini Hospital , Jiroft University of Medical Sciences , Jiroft , Iran

8. Psychiatry and Behavioral Sciences Research Center , Mashhad University of Medical Sciences , Mashhad , Iran

9. Department of Physiology, School of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran

10. Applied Biomedical Research Center , Mashhad University of Medical Sciences , Mashhad , Iran

Abstract

Abstract Objectives This study aimed to investigate the antioxidant effect of rosiglitazone (ROG) and pioglitazone (POG) on oxidative damage and dysfunction of hepatic tissue in hypothyroid rats. Methods The male rats were classified into six groups: (1) Control; (2) Hypothyroid, (3) Hypothyroid-POG 10, (4) Hypothyroid-POG 20, (5) Hypothyroid-ROG 2, and (6) Hypothyroid-ROG 4. To induction hypothyroidism in rats, propylthiouracil (PTU) (0.05 %w/v) was added to drinking water. In groups 2–6, besides PTU, the rats were also intraperitoneal administrated with 10 or 20 mg/kg POG or 2 or 4 mg/kg ROG for six weeks. Finally, after deep anesthesia, the blood was collected to measure the serum biochemical markers and hepatic tissue was separated for biochemical oxidative stress markers. Results Administration of PTU significantly reduced serum thyroxin concentration, total thiol levels, activity of superoxide dismutase (SOD) and catalase (CAT) enzymes, and increased serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (Alk-P) and malondialdehyde (MDA) in the liver. Additionally, our results showed that prescription of POG or ROG for six weeks to hypothyroid rats resulted in an improvement in liver dysfunction (decrease in serum levels of AST, ALT, and ALK-P) through reducing oxidative damage in hepatic tissue (increase in CAT, SOD, or total thiols and decrease in MDA levels). Conclusions The findings of the present study presented that the IP administration of POG and ROG for six weeks improves liver dysfunction induced by hypothyroidism in juvenile rats by reducing oxidative damage.

Funder

Mashhad University of Medical Sciences, Mashhad, Iran

Publisher

Walter de Gruyter GmbH

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