A solid lipid particle formulation of long pepper extract reduces pain and astrocyte activation in a rat model of neuropathic pain-Reference-Cited by-同舟云学术

A solid lipid particle formulation of long pepper extract reduces pain and astrocyte activation in a rat model of neuropathic pain

Published:2023-09-18 Issue:4 Volume:20 Page:714-720
ISSN:1553-3840
Container-title:Journal of Complementary and Integrative Medicine
language:en
Short-container-title:

Author:

Iamjan Sri-arun¹,Veerasakul Siriluk²,Thanoi Samur³,Tiyaboonchai Waree⁴,Nudmamud-Thanoi Sutisa⁵⁶^ORCID

Affiliation:

1. Department of Medical Sciences , Faculty of Allied Health Sciences, Burapha University , Chonburi , Thailand

2. School of Allied Health Sciences and Public Health , Walailak University , Nakhon Si Thammarat , Thailand

3. School of Medical Sciences , University of Phayao , Phayao , Thailand

4. Department of Pharmaceutical Technology , Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand

5. Department of Anatomy , Faculty of Medical Science, Naresuan University , Phitsanulok , Thailand

6. Centre of Excellence in Medical Biotechnology , Faculty of Medical Science, Naresuan University , Phitsanulok , Thailand

Abstract

Abstract Objectives To investigate the effects of solid lipid microparticle (SLM) creams containing a long pepper extract (LPE) or piperine on neuropathy-related pain and the expression of glial fibrillary acidic protein (GFAP) as a measure of astrogliosis. Methods Neuropathic pain in male Spraque Dawley rats was induced by sciatic nerve ligation (SNL) and followed by treatment with LPE-SLM, piperine-SLM, capsaicin or vehicle creams. The pain score was assessed by thermal hyperalgesia test. The GFAP expression in the spinal cord was determined by immunohistochemistry. Results Pain scores were significantly increased after SNL and decreased when treated by LPE-SLM. The number of GFAP immunopositive cells was significantly increased in the SNL rats. Treated by LPE-SLM and capsaicin creams resulted in a significant reduction of the number of GFAP immunopositive cells. The LPE-SLM treated rats showed greater effects than the piperine and capsaicin preparations. Conclusions The LPE-SLM cream has a potential effect on pain attenuation via a decrease of spinal astrocyte activation-related mechanism. The LPE in SLM preparation could provide an alternative therapeutic strategy for treating neuropathic pain.

Funder

Naresuan University

Publisher

Walter de Gruyter GmbH

Subject

Complementary and alternative medicine

Link

https://www.degruyter.com/document/doi/10.1515/jcim-2023-0043/pdf

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