Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases-Reference-Cited by-同舟云学术

Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases

Published:2022-09-06 Issue:3 Volume:34 Page:275-294
ISSN:0334-1763
Container-title:Reviews in the Neurosciences
language:en
Short-container-title:

Author:

Shi Wenjia¹,Tan Cheng¹,Liu Can¹,Chen Dan¹

Affiliation:

1. Department of Anatomy and Neurobiology , School of Basic Medical Science, Central South University , Changsha 410013 , Hunan Province , China

Abstract

Abstract In recent years, the role of mitochondrial dynamics in neurodegenerative diseases has becoming increasingly important. More and more evidences have shown that in pathological conditions, abnormal mitochondrial divisions, especially Drp1-Fis1-mediated divisions, play an important role in the occurrence and development of Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease, glaucoma, and other neurodegenerative diseases. This review highlights several new mechanisms of physiological fission of mitochondria and the difference/connection of physiological/pathological mitochondrial fission. In addition, we described the relationship between abnormal mitochondrial dynamics and neurodegenerative diseases in detail and emphatically summarized its detection indicators in basic experiments, trying to provide references for further mechanism exploration and therapeutic targets.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/revneuro-2022-0056/pdf

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