Balo’s concentric sclerosis: an update and comprehensive literature review

Author:

Amini Harandi Ali1,Esfandani Akram1,Pakdaman Hossein1,Abbasi Mehdi1,Sahraian Mohammad Ali2

Affiliation:

1. Brain Mapping Research Center , Shahid Beheshti University of Medical Sciences , Tehran 1333635445 , Iran

2. MS Research Center, Neuroscience Institute , Tehran University of Medical Sciences , Tehran 1136746911 , Iran

Abstract

Abstract Balo’s concentric sclerosis (BCS) is considered a variant of multiple sclerosis characterized by concentric lamella of alternating demyelinated and partially myelinated tissues. It is a rare and a relatively acute condition. Attacks may proceed rapidly over weeks or months, typically without remission, like Marburg’s variant, resulting in death or severe disability. However, the majority of cases have a more benign, self-limiting course with spontaneous remission. Magnetic resonance imaging is a primary imaging modality in the diagnosis of BCS. Treatment with intense immunosuppression may be indicated in patients with more aggressive form. New reports reveal more evidence regarding the pathophysiology and treatment strategies.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

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