Effect of Chronic Social Stress on Endothelial Function of the Mesenteric Artery of Normotensive and Spontaneously Hypertensive Rats-Reference-Cited by-同舟云学术

Effect of Chronic Social Stress on Endothelial Function of the Mesenteric Artery of Normotensive and Spontaneously Hypertensive Rats

Published:2016-09-01 Issue:1 Volume:63 Page:23-24
ISSN:2453-6725
Container-title:European Pharmaceutical Journal
language:en
Short-container-title:

Author:

Kaprinay B.¹²,Bernatova I.³,Sotnikova R.⁴

Affiliation:

1. Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava, Slovak Republic Slovakia

2. Comenius University in Bratislava,Jessenius Faculty of Medicine in Martin, Institute of Pharmacology, Martin, Slovakia

3. Slovak Academy of Sciences, Institute of Normal and Pathologycal Physiology, Bratislava, Slovakia

4. Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava, Slovakia

Abstract

Abstract The aim of the work was to study the effect of chronic social stress induced by increased population density, “crowding stress” on blood pressure and endothelial function of arteries of male normotensive Wistar and spontaneously hypertensive (SHR) rats. Based on the results, we assume that social stress-induced reduction in endothelium-dependent relaxation and increased blood pressure of SHR rats is most likely associated with decreased bioavailability of nitric oxide.

Publisher

Walter de Gruyter GmbH

Subject

General Pharmacology, Toxicology and Pharmaceutics

Reference5 articles.

1. [1] Bennett MA, Hillier C, Thurston H. Endothelium-dependent relaxation in resistance arteries from spontaneously hypertensive rats: effect of long-term treatment with perindopril, quinapril, hydralazine or amlodipine. J Hypertens. 1996;14:389-397.

2. [2] Bernatova I, Pechanova O, Kristek F. Mechanism of structural remodeling of the rat aorta during long-term NG-nitro-L-arginine methyl ester treatment. Jap J Pharmacol. 1999;81:99-106.

3. [3] Fujii K, Ohmori S, Tominaga M, Abe I, Takata Y, Ohya Y, Kobayashi K, Fujishima M. Age-related changes in endothelium-dependent hyperpolarization in the rat mesenteric artery. Am J Physiol. 1999;265:H509-519.

4. [4] Jankyova S, Hlavackova L, Kralova E, Slazneva J, et al. The evaluation of efficacy of pycnogenol® fractions on endothelial dysfunction. Acta Fac Pharm Univ Comen. 2013;60:7-14.

5. [5] Non AL, Rimm EB, Kawachi I, Rewak MA, Kuzansky LD. The effects of stress at work and at home on inflammation and endothelial dysfunction. PloS ONE 2014;9:e94474.