A new method for isolating (E)-azastilbene derivatives with antimicrobial properties from aqueous samples

Abstract

Abstract This paper presents the results of a study aimed at developing the extraction process and determining long-term stability of (E)-azastilbene derivatives in order to explore their possible use as preservative, antiseptic and disinfectant substances. The study was performed in three different matrices: distilled, surface and waste water. Test substances included bromide of (E)-N-(o-bro-mobenzyl)-4′-hydroxystilbazole-4 and chloride of (E)-N-(p-chlorobenzyl)-4′-hydroxystilbazole-4. The extraction process involved the use of three stationary phases: octyl, octadecyl and naphthylpropyl. The highest recovery values (amounting to approx. 95%) were obtained in the naphthylpropyl column for all of the above-mentioned matrices. A decline in the stability of the analysed derivatives after a 28-day period was below 14% in all matrix types.