Affiliation:
1. General hospital of Nova Gorica , Ulica padlih borcev 13a, 5290 Šempeter Pri Gorici , Slovenia
2. University Clinic Golnik , Golnik , Slovenia
3. Faculty of Sport , University of Ljubljana , Slovenia, Ljubljana , Slovenia
Abstract
Abstract
Background
The insulin-like growth factor 1 receptor (IGF1R) expression has been addressed as a potential prognostic marker in non-small-cell lung cancer (NSCLC) in various studies; however, the associations between IGF1R expression and prognosis of advanced NSCLC patients is still controversial. The aim of our observational, cohort study was to evaluate the expression of IGF1R in advanced NSCLC and its prognostic role. A subgroup analysis was performed to address the influence of pre-existing type 2 diabetes mellitus (T2DM) status on IGF1R expression and overall survival (OS).
Patients and methods
IGF1R expression was evaluated in 167 consecutive advanced NSCLC patients (stage IIIB and IV), diagnosed and treated at one university institution, between 2005 and 2010. All patients received at least one line of standard cytotoxic therapy and 18 of them had pre-existing T2DM. IGF1R expression was determined by immunohistochemical (IHC) staining, with score ≥ 1+ considered as positive. Information on baseline characteristics, as well as patients’ follow-up data, were obtained from the hospital registry. Associations of IGF1R expression with clinical characteristics and overall survival were compared.
Results
IGF1R expression was positive in 79.6% of patients, significantly more often in squamous-cell carcinoma (SCC) compared to non-squamous-cell (NSCC) histology (88.7% vs. 74.3%; P = 0.03). IGF1R positivity did not correlate with T2DM status or with other clinical features (sex, smoking status, performance status). Median OS was similar between IGF1R positive and IGF1R negative group (10.2 vs. 8.5 months, P = 0.168) and between patients with or without T2DM (8.7 vs. 9.8 months, P = 0.575). Neither IGF1R expression nor T2DM were significant predictors of OS.
Conclusions
IGF1R or T2DM status were not significantly prognostic in described above collective of advanced NSCLC treated with at least one line of chemotherapy. In addition, no association between T2DM status and IGF1R expression was found. Further studies on IGF1R expression and its prognostic as well as therapeutic consequences in a larger collective of advanced NSCLC patients, with or without T2DM, are needed.
Subject
Radiology Nuclear Medicine and imaging,Oncology
Reference66 articles.
1. International Agency for Research on Cancer. World health Organization. GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 20012. Lung cancer fact sheet. [Citated 2016 Jun 15]. Available at http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx?cancer=lung.
2. Morgensztern D, Ng SH, Gao F, Govindan R. Trends in stage distribution for patients with non-small cell lung cancer: A National Cancer Database survey. J Thorac Oncol 2010; 5: 29-33. 10.1097/JTO.0b013e3181c5920c
3. Debevec L, Jerič T, Kovač V, Bitenc M, Sok M. Is there any progress in routine management of lung cancer patients? A comparative analysis of an institution in 1996 and 2006. Radiol Oncol 2009; 43: 47-53. 10.2478/v10019-009-0008-x
4. Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Altekruse SF, et al.SEER cancer statistics review, 1975-2013. Bethesda: National Cancer Institute. [Citated 2016 Sept 04]. Available at http://seer.cancer.gov/csr/1975_2013/
5. Sechler M, Cizmic AD, Avasarala S, Van Scoyk M, Brzezinski C, Kelley N, et al. Non-small-cell lung cancer: molecular targeted therapy and personalized medicine – drug resistance, mechanisms, and strategies. Pharmgenomics Pers Med 2013; 6: 25-36. 10.2147/PGPM.S26058
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