Emerging in ovo technologies in poultry production and the re-discovered chicken model in preclinical research
Author:
Niloofar Akhavan12, Marek Bednarczyk3, Krzysztof Krajewski4, Katarzyna Stadnicka2
Affiliation:
1. Department of Microbiology , Faculty of Biology and Veterinary Science , Nicolaus Copernicus University , Toruń , Poland 2. Oncology Department , Collegium Medicum of Ludwik Rydygier in Bydgoszcz, Nicolaus Copernicus University , Bydgoszcz , Poland 3. Department of Animal Biotechnology and Genetics , Bydgoszcz University of Science and Technology , Bydgoszcz , Poland 4. Vetdiagnostica Sp. z o.o. , Makowiska , Poland
Abstract
Abstract
Prenatal programming is a concept based on assumptions that the events occurring in critical points of embryonic development may pose epigenetic changes resulting from chemical rearrangements on the DNA structure. Epigenetic changes may pose life lasting phenotypic effects in the animal, or can be heritable, like gene silencing associated with methylation in gene promoters regions. The technical advancements in biotechnology, bioinformatics, molecular techniques and robotization have brought to new technological applications in poultry production. Intentional stimulation of embryonic development and determination of the future health of the hatched organism is possible by in ovo application of natural antioxidants and prebiotics, gut stabilizers like probiotics and other immunological enhancements, including vaccines. In parallel, the fine-tuned and generally accessible techniques of chicken embryo incubation along with the novel tissue engineering tools have led to focus the attention of scientists on chicken embryo as the alternative animal model for some pre-clinical approaches, in the context of reducing and replacing the experiments on animals. In this chapter, some key highlights are provided on current achievements in poultry embryonic applications, with the attention put to the emerging in ovo technologies (in ovo feeding, immunological stimulation and in ovo oncological tools), that address the societal challenges in food production and health management.
Funder
Narodowe Centrum Nauki Ministerstwo Edukacji i Nauki
Publisher
Walter de Gruyter GmbH
Subject
General Physics and Astronomy,General Materials Science,General Chemistry
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