Quantitative Evaluation of the Reactivity of Alkylating Agents-Reference-Cited by-同舟云学术

Quantitative Evaluation of the Reactivity of Alkylating Agents

Published:1980-06-01 Issue:6 Volume:35 Page:758-763
ISSN:1865-7117
Container-title:Zeitschrift für Naturforschung B
language:en
Short-container-title:

Author:

Bodor Nicholas¹,Kaminski James J.²,Worley S. D.³,Gerson Steven H.¹

Affiliation:

1. Department of Medicinal Chemistry, College of Pharmacy, J. Hillis Miller Health Center, University of Florida, Gainesville, Florida 32610

2. Schering Corporation, Bloomfield, N. J. 07003

3. Department of Chemistry, Auburn University, Auburn, Alabama 36830

Abstract

Abstract A sensitive and reproducible method for quantitative evaluation of the relative reactivities of alkylating agents was developed, based on competitve alkylation. The method is superior to the known colorimetric methods. The reactivities of the agents could also be correlated with the 13C chemical shifts of the α-methylene. The method was successfully applied for the ranking of "soft" alkylating agents of low reactivity.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/znb-1980-0625/pdf

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