Facile synthesis of model 2,4-diaryl-1,3,4-thiadiazino[5,6-h]fluoroquinolones-Reference-Cited by-同舟云学术

Facile synthesis of model 2,4-diaryl-1,3,4-thiadiazino[5,6-h]fluoroquinolones

Published:2019-05-21 Issue:6 Volume:74 Page:507-512
ISSN:1865-7117
Container-title:Zeitschrift für Naturforschung B
language:en
Short-container-title:

Author:

Abadleh Mohammed M.¹,Arafat Tawfiq²,Abu-Qatouseh Luay²,El-Abadelah Mustafa M.³,Awwadi Firas F.³,Voelter Wolfgang⁴

Affiliation:

1. Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy , University of Petra , Amman 11196 , Jordan

2. Faculty of Pharmacy, University of Petra , Amman 11196 , Jordan

3. Department of Chemistry , Faculty of Science, The University of Jordan , Amman 11942 , Jordan

4. Interfakultaeres Institut fuer Biochemie, Universitaet Tuebingen , Hoppe-Seyler Strasse 4 , Tuebingen 72076 , Germany

Abstract

Abstract A Selected set of 2,4-diaryl-7-oxo-1,2,4-thiadiazino[5,6-h]quinoline-8-carboxylic acids 6a–e has been prepared via reaction of the parent 7-chloro-8-nitro-10-cyclopropyl-6-fluoroquinolone 4 with the appropriate N′-(aryl)benzothiohydrazide 5a–e in presence of triethylamine. Structures of the new heterocyclics 6a–e are supported by spectral data and confirmed by single-crystal X-ray crystallography for 6a.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/znb-2019-0023/pdf

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