Unforgettable force – crosstalk and memory of mechanosensitive structures
Author:
Kanoldt Verena1, Fischer Lisa1, Grashoff Carsten12ORCID
Affiliation:
1. Group of Molecular Mechanotransduction , Max Planck Institute of Biochemistry , 82152 Martinsried , Germany 2. Department of Quantitative Cell Biology , Institute of Molecular Cell Biology, University of Münster , 48149 Münster , Germany
Abstract
Abstract
The ability of cells to sense and respond to mechanical stimuli is crucial for many developmental and homeostatic processes, while mechanical dysfunction of cells has been associated with numerous pathologies including muscular dystrophies, cardiovascular defects and epithelial disorders. Yet, how cells detect and process mechanical information is still largely unclear. In this review, we outline major mechanisms underlying cellular mechanotransduction and we summarize the current understanding of how cells integrate information from distinct mechanosensitive structures to mediate complex mechanoresponses. We also discuss the concept of mechanical memory and describe how cells store information on previous mechanical events for different periods of time.
Publisher
Walter de Gruyter GmbH
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
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