In the Search for New Anticancer Drugs, I Antitumor Activity of Various Nitroxyl- and Aziridine-Containing Phosphorus Compounds-Reference-Cited by-同舟云学术

In the Search for New Anticancer Drugs, I Antitumor Activity of Various Nitroxyl- and Aziridine-Containing Phosphorus Compounds

Published:1981-07-01 Issue:7 Volume:36 Page:888-891
ISSN:1865-7117
Container-title:Zeitschrift für Naturforschung B
language:en
Short-container-title:

Author:

Konieczny Maria¹,Sosnovsky George²,Gutierrez Peter³

Affiliation:

1. Ben May Laboratory for Cancer Research, The University of Chicago, Chicago, Illinois 60637 U.S.A.

2. Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201 U.S.A

3. Laboratory of Clinical Biochemistry, BCRP, DCT, NCI, NIH, Baltimore, Maryland 21201 U.S.A.

Abstract

Abstract A series of pentavalent phosphorus compounds containing the nitroxyl and/or aziridinyl moieties was evaluated for antitumor activity against P 388 and L 1210 lymphocytic leukemias, and compared to the clinical agent thio-TEPA (1). The compounds with the structures 5-13 were found to be active, with a T/C value greater than 125. The percent ILS was also determined.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/znb-1981-0718/pdf

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1. In the Search for New Anticancer Drugs. 26. A Comparison of Anticancer Activities of Several TEPA, Thio-TEPA, Seleno-TEPA, and Azetidine Analogs, Including Congeners Containing an Aminoxyl Moiety;Journal of Pharmaceutical Sciences;1994-07

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