Beeinflussung der osmotischen Hämolyse durch Benzimidazol-Lost-Derivate bei der Maus

Abstract

By means of a new parameter “t” characterizing the time course of osmotic haemolysis registered spectrophotometrically it has been described more comprehensively the membrane stabilizing effect of biological active substances. Extent and time course of osmotic haemolysis can be varied after the influence of any stabilizing drugs in different patterns. Both substances, IMET 3393 (γ-[1-methyl-5-bis- (β-chloraethyl) -amino-benzimidazol- (2)] -butyric acid · HCl) and IMET 3164 (β- [1-phenyl-5-bis- (β-chloraethyl) -amino-benzimidazolyl- (2)] -DL-alanine), respectively, i.p. applicated have increased the osmotic resistance and have delayed also the haemolysis of red blood cells in mice. The method was proved in vitro by chlorpromazine. This agent, however, has alterated only the resistance of erythrocytes but the parameter “t” was not influenced.