Antiproliferative effect of synthetic cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against human cancer cell lines-Reference-Cited by-同舟云学术

Antiproliferative effect of synthetic cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against human cancer cell lines

Published:2016-10-21 Issue:11-12 Volume:71 Page:423-427
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Stiz Dorimar¹,Campos Adriana¹,Lúcia Tasca Gois Ruiz Ana²,Ernesto de Carvalho João²,Corrêa Rogério¹,Cechinel-Filho Valdir³

Affiliation:

1. Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí – UNIVALI, Itajaí, Santa Catarina, Brazil

2. Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA) – Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil

3. Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí – UNIVALI, Caixa postal 360, CEP 88302-202, Itajaí, Santa Catarina, Brazil , Tel.: +55-473-341-7557

Abstract

Abstract This work describes the antiproliferative potential of 14 cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against several human cancer cell lines. The antiproliferative effect was evaluated using the sulforhodamine B assay. Although some compounds from methylphtalimide and carboxylic acid phtalimide classes exhibited a selective antiproliferative activity, the itaconimides (11–14) exhibited the best results, especially compound 14, which presented a TGI (concentration that produces total growth inhibition) value of 0.0043 μM against glioma (U251), being inactive against the non-tumor cell line (HaCat). Absorption, distribution, metabolism and excretion in silico evaluations suggest that these compounds are promising candidates.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2016-0067/pdf

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