Automated insulin delivery in children with type 1 diabetes during physical activity: a meta-analysis
Author:
Wang Yuan-yuan1, Ying Hui-min1, Tian Fang1, Qian Xiao-lu1, Zhou Zhen-feng2, Zhou Chun-cong3
Affiliation:
1. Department of Endocrinology , 631689 Xixi Hospital of Hangzhou , Hangzhou , Zhejiang Province , P.R. China 2. Department of Anesthesiology , Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital, Hangzhou First People’s Hospital Qianjiang New City Campus, Zhejiang Chinese Medical University) , Hangzhou , P.R. China 3. Department of Urolithiasis and Anorectal Surgery , Ningbo No. 2 Hospital , Ningbo , Zhejiang Province , P.R. China
Abstract
Abstract
Objectives
The aim of this study was to evaluate the performance of the automated insulin delivery (AID) in adolescents, and children with type 1 diabetes (T1D) during physical activity.
Methods
Relevant studies were searched electronically in the Cochrane Library, PubMed, and Embase utilizing the key words “Child”, “Insulin Infusion Systems”, and “Diabetes Mellitus” from inception to 17th March 2024 to evaluate the performance of the AID in adolescents, and children with T1D during physical activity.
Results
Twelve studies involving 514 patients were identified. AID did not show a beneficial effect on duration of hypoglycemia<70 mg/dL during study period (p>0.05; I2=96 %) and during the physical activity (p>0.99). Percentage of sensor glucose values in TIR was higher in AID than the non-AID pumps during study period (p<0.001; I2=94 %). The duration of hyperglycemic time was significantly decreased in AID group compared to the non-AID pumps group during study period (p<0.05; I2>50 %).
Conclusions
AID improved TIR and decreased the duration of hyperglycemic time, but did not appear to have a significant beneficial effect on the already low post-exercise duration of hypoglycemia achievable by open loop or sensor-augmented pumps in adolescents and children with T1D during physical activity; further research is needed to confirm the beneficial effect of AID on duration of hypoglycemia.
Publisher
Walter de Gruyter GmbH
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