Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome
Author:
Guzelkas Ismail1, Orbak Zerrin2, Doneray Hakan2, Ozturk Nurinnisa3, Sagsoz Nevin4
Affiliation:
1. Department of Pediatrics , Ataturk University Faculty of Medicine , Erzurum , Turkey 2. Department of Pediatric Endocrinology , Ataturk University Faculty of Medicine , Erzurum , Turkey 3. Department of Biochemistry , Ataturk University Faculty of Medicine , Erzurum , Turkey 4. Department of Obstetrics and Gynecology , Kırıkkale University Faculty of Medicine , Kırıkkale , Turkey
Abstract
Abstract
Objectives
Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction, clinical and/or biochemical hyperandrogenism, and polycystic ovaries. Its pathogenesis is still unclear. This study aimed to investigate the relationship between kisspeptin, leptin, neuropeptide Y (NPY), and neurokinin B (NKB) levels for evaluating the pathogenesis of PCOS.
Methods
Levels of these parameters were analyzed in 20 patients with PCOS, and 16 healthy adolescents.
Results
Serum NPY levels were significantly higher in the obese and non-obese PCOS group (p<0.01). There was a negative correlation between the kisspeptin and the NKB levels (p<0.01) in the PCOS group but not in the control group. This negative correlation was also found in both PCOS groups (p<0.01). In the obese PCOS group, serum kisspeptin levels were significantly lower than the control and non-obese PCOS groups (p<0.05) although serum leptin and NPY levels were significantly higher in the obese PCOS group (p<0.01).
Conclusions
The high NPY levels in both obese and non-obese patients with PCOS indicate that NPY plays a role in the pathogenesis independently from obesity. Significantly high leptin and low kisspeptin levels in the obese PCOS group suggested that they may be associated with obesity rather than PCOS.
Publisher
Walter de Gruyter GmbH
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology and Child Health
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