Electrical vestibular nerve stimulation as an adjunctive therapy in the management of type 2 diabetes

Author:

Goothy Sai Sailesh Kumar1ORCID,McKeown Jason234,D. Mcgeoch Paul5,B Srilatha6,Vijayaraghavan Rajagopalan7,Manyam Ravikanth8,Vijay Khanderao Mahadik9

Affiliation:

1. Department of Physiology, R.D.Gardi Medical College , Ujjain , India

2. Center for Brain and Cognition, UC San Diego , San Diego , USA

3. Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast , UK

4. Neurovalens Ltd. , Belfast , UK

5. Center for Brain and Cognition , UC San Diego , USA

6. Department of Biochemistry, R.D.Gardi Medical College , Ujjain , Madhya Pradesh , India

7. Department of Research and Development, Saveetha Institute of Medical and Technical Sciences (SIMATS) , Chennai , Tamil Nadu , India

8. Department of Oral Pathology, Vishnu Dental College , Bhimavaram , Andhra Pradesh , India

9. R.D.Gardi Medical College , Ujjain , Madhya Pradesh , India

Abstract

Abstract Objectives Vestibular nerve stimulation using the portable battery-operated vestibular nerve stimulator is a sophisticated method noninvasive, safe, and easy to operate. It was hypothesized that vestibular nerve stimulation is effective in the management of type 2 diabetes. Hence, the present study was undertaken to determine the effectiveness of vestibular nerve stimulation using portable battery-operated vestibular nerve stimulator in the management of diabetes. Methods The present study was a double-blind randomized controlled trial with 1:1 split between the control and experimental groups. A total of 30 participants with type 2 diabetes were part of the study after obtaining the written informed consent. After recording the baseline values, the vestibular nerve stimulation was administered to the participants in the intervention group for 90 days. Sham stimulation was administered to the control group for 90 days. Outcome measures were recorded after 30 days and after 90 days of the intervention in both the groups. Results There was significant decrease in the total body weight, fasting, postprandial blood glucose, glycosylated hemoglobin levels, leptin, very low density lipoproteins levels followed by the intervention. There was significant improvement in both spatial and verbal memory scores. Depression and stress scores and systolic blood pressure decreased and remained in normal limits. Conclusions The study results have proven multimodal action of vestibular stimulation. It not only acts on regulation of the glucose metabolism but also can regulate the autonomic activity and improve cognition and relieve stress. This is the interesting finding of our study, which needs detailed further research to support implementation of vestibular nerve stimulation as an adjunctive therapy in the management of diabetes.

Funder

Neurovalance

Publisher

Walter de Gruyter GmbH

Subject

Drug Discovery,Pharmacology,General Medicine,Physiology

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Non-Pharmacological Management of Insomnia Through Electrical Vestibular Stimulation (VeNS);Current Sleep Medicine Reports;2024-04-13

2. Anxiolytic effects of vestibular stimulation: an update;Journal of Basic and Clinical Physiology and Pharmacology;2023-04-19

3. Effectiveness of electrical vestibular nerve stimulation on the range of motion in patients with Parkinson’s disease;Journal of Basic and Clinical Physiology and Pharmacology;2022-10-10

4. Research Progress of Vestibular Stimulation Regulating Hypothalamus on Obesity;Highlights in Science, Engineering and Technology;2022-08-17

5. Electrical vestibular nerve stimulation (VeNS): a follow-up safety assessment of long-term usage;Journal of Basic and Clinical Physiology and Pharmacology;2022-03-14

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