Effect of Thio- and Hydrazino-derivatives of Uracil, 6-Azauracil and 6-Azathymine on the Growth of Some Microorganisms in Vitro

Author:

Spassov Alexander1,Golovinsky Evgeny1,Spassovska Nadejda1,Maneva Liliana1

Affiliation:

1. Biochemical Research Laboratory, Bulgarian Academy of Sciences, Sofia, Bulgaria

Abstract

The antibacterial activity of 2-thiouracil, 2-methylthiouracil, 2-hydrazinouracil, 2,4-dithiouracil, 2-thio-4-hydrazinouracil, 2-thio-6-azathymine, 2-hydrazino-6-azathymine, 2,4-dithio-6-azathymine, 2-thio-4-hydrazino-6-azathymine, 2,4-dimethylthio-6-azathymine, 2-methylthio-4-hydrazino-6-azathymine, 4-thio-6-azauracil and 4-hydrazino-6-azauracil has been studied on the growth of: Staphylococcus aureus 209, Streptococcus faecalis 775, Escherichiia coli 387, Pseudomonas aeruginosa, Bacillus subtilis, Candida tropicalis and Neurospora crassa 9863. The highest inhibitory effect was observed with 4-hydrazino-derivatives of 2-thiouracil, 6-azauracil and 2-thio-6-azathymine.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

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