Radioiodination of olmesartan medoxomil and biological evaluation of the product as a tracer for cardiac imaging-Reference-Cited by-同舟云学术

Radioiodination of olmesartan medoxomil and biological evaluation of the product as a tracer for cardiac imaging

Published:2017-11-14 Issue:4 Volume:106 Page:329-336
ISSN:2193-3405
Container-title:Radiochimica Acta
language:en
Short-container-title:

Author:

Sanad M. H.¹,Marzook Ebtisam. A.²,Challan Safaa B.³

Affiliation:

1. Labeled Compounds Department , Hot Labs Center, Egyptian Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt , E-mail:

2. Biological Application Department , Nuclear Research Center, Egyptian Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt

3. Nuclear Physics Department , Cyclotron Project, Nuclear Research Center, Egyptian Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt

Abstract

Abstract The present study is oriented to synthesis of radioiodinated olmesartan medoxomil (OM) for potential cardiac imaging. Olmesartan medoxomil has been labeled with [125/131I] using chloramine-T (Ch-T) as an oxidizing agent. The key effective factors such as amount of oxidizing agent, amount of substrate, pH, reaction temperature and reaction time, have been systematically studied to get high radiochemical yield of the [125I]olmesartan medoxomil reaching values of 98.5%. The labeled compound was separated and purified using thin layer chromatography (TLC), paper electrophoresis and high performance liquid chromatography (HPLC). The biological distribution indicates the suitability of [125I]olmesartan medoxomil as a novel tracer to image heart with high heart/blood ratio within 30 min which was detected by gamma camera.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/ract-2017-2830/pdf

Reference28 articles.

1. Nicholls, M. G., Richards, A. M., Agarwal, M.: The importance of the renin-angiotensin system in cardiovascular disease. J. Hum. Hypertens. 12, 295 (1998).10.1038/sj.jhh.1000638

2. Balt, J. C., Mathy, M. J., Pfaffendorf, M., van Zwieten, P. A.: Inhibition of facilitation of sympathetic neurotransmission and angiotensin II-induced pressor effects in the pithed rat: comparison between valsartan, candesartan, eprosartan and embusartan. J. Hypertens. 19(12), 2241 (2001).10.1097/00004872-200112000-00018

3. Kenakin, T.: Competitive antagonism. In: C. Boselli (Ed.), Pharmacologic Analysis of Drug-Receptor Interaction. 3rd ed. Philadelphia, Lippincot & Raven Publishers. 331 (1997).

4. Skugor, M.: Thyroid Disorders. A Cleveland Clinic Guide. Cleveland Clinic Press, The Amazon Book Review, p. 82. ISBN 978-1-59624-021-6. (2006).

5. Robbins, J., Schneider, A. B.: Thyroid cancer following exposure to radioactive iodine. Rev. Endocr. Metab. Disord. 1(3), 197 (2000).10.1023/A:1010031115233

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