Affiliation:
1. Research Unit of Medical, Agricultural and Environmental Use of Nuclear Applications, CNSTN, 2020 Sidi Thabet, Tunisia
Abstract
Abstract
The synthesis, characterization and biological evaluation of
N-Tolueneferrocenecarboxamide labeled with technetium-99m
(99mTc-TTCC) is reported. Biological studies in
Wistar rats showed the ability of 99mTc-TPCC to
cross the intact blood-brain barrier.
In vivo biodistribution
indicated that this complex had good brain uptake
(1.32% ID/g at 5 min and 0.64% ID/g
at 60 min) and good retention (about 50% of the
activity was retained in the brain at 60 min
post-injection). Regional brain distribution study showed that
hippocampus, where the 5-HT1A receptor density is high, had the
highest uptake (0.73% ID/g at 5 min p.i.) and
the cerebellum, where the 5-HT1A receptor density is low, had the
lowest uptake (0.12% ID/gID/g at 5 min
p.i.). After blocking with 8-hydroxy-2-(dipropylamino) tetralin, the
uptake of hippocampus was decreased significantly from
0.73% ID/g to 0.20% ID/g at 5 min
p.i., while the cerebellum had no significant decrease. This result
indicates that 99mTc complex has specific binding to 5-HT1A receptor.
Subject
Physical and Theoretical Chemistry
Cited by
4 articles.
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