Radioiodination, diagnostic nuclear imaging and bioevaluation of olmesartan as a tracer for cardiac imaging

Author:

Sanad H. M.1,Ibrahim Alhussein A.2

Affiliation:

1. Labelled Compounds Department, Radioisotopes Production and Radioactive Sources Division , Hot Laboratories Center, Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt

2. Applied Organic Chemistry Department, Organic Chemical Industries Division , National Research Center , Cairo 12622 , Egypt

Abstract

Abstract The present work has been oriented to prepare radioiodinated olmesartan for a potential cardiac imaging. Olmesartan has been labeled using 125I or 131I with N-bromosuccinimide (NBS) as an oxidizing agent. Many factors like amount of N-bromosuccinimide, amount of substrate, pH, reaction temperature and reaction time, have been systematically studied to optimize high yield of [125I]iodoolmesartan. The biological distribution indicates the suitability of [125I]iodoolmesartan as a novel tracer to image heart.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

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