Author:
Rádl Stanislav,Zikán Viktor,Šmejkal František
Abstract
The paper describes syntheses of 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ia), its 1-methyl derivative (Ib), 2-methyl derivative (IIa), 9-methyl derivative (Ic), 1,9-dimethyl derivative (Id) and 2,9-dimethyl derivative (IIb). Sodium salts of compounds Ia, Ib, Ic and IIa were methylated with methyl iodide in dimethylformamide at room temperature, compounds Id and IIb were demethylated with pyridine hydrochloride. The compounds prepared were tested for antiviral activity in vivo in mice against influenza virus A2-Hongkong and the Encephalomyocarditis virus.
Publisher
Institute of Organic Chemistry & Biochemistry
Cited by
19 articles.
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1. 1H-Pyrazolo[3,4-b]quinolines: Synthesis and Properties over 100 Years of Research;Molecules;2022-04-26
2. One‐pot, three‐component synthesis of polyfunctionalized benzo[
h
]pyrazolo[3,4‐
b
][1,6]naphthyridine and benzo[
g
]pyrazolo[3,4‐
b
]quinoline derivatives in the presence of silver nanoparticles (
AgNPs
);Journal of Heterocyclic Chemistry;2020-08-26
3. An Efficient One-Pot, Four-Component Synthesis of Pyrazolo[3,4-b]pyridines Catalyzed by Tetrapropylammonium Bromide (TPAB) in Water;Australian Journal of Chemistry;2018
4. Convenient regioselective reaction in presence of H3PW12O40: synthesis and characterization of pyrazolo[3,4-b]quinoline-3,5-diones;Research on Chemical Intermediates;2017-09-15
5. WITHDRAWN: Application of Fe3O4/PEG-SO3H as heterogeneous and magnetically recyclable nanocatalyst for one-pot three-component synthesis of 3-methyl-4-aryl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridine-6-ones;Catalysis Today;2017-06