Author:
Kasal Alexander,Zajíček Jaroslav
Abstract
Action of some nucleophilic reagents (CH3COOAg, CH3COOK, LiAlH4) on 6β-chloro- and 6β-methanesulfonyloxy-5-methyl-19-nor-5β-cholest-9-enes VIII - XII affords predominantly A-homo-B,19-dinor-5β-cholest-9-ene derivatives, arising by rearrangement and substitution (XIII, XXIV) or rearrangement and elimination (e.g. XX). Hydrogenolysis of compounds of the type VIII with lithium aluminium hydride gives, in addition, a product of rearrangement, fragmentation and further reduction (XXVI), and 5-methyl-6α,10-cyclo-19-nor-5β,9β,10α-cholestan-3β-ol (XXX).
Publisher
Institute of Organic Chemistry & Biochemistry
Cited by
8 articles.
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