Inhibition of nucleic acid synthesis in L1210 cells by nucleoside analogs

Abstract

Series of pyrimidine nucleoside analogs were tested for inhibition of DNA and/or RNA synthesis at L1210 cells. The structure-activity relationship was studied at the analogs of cancerostatic agents 5-fluorouracil and arabinosylcytosine. Out of them the 5'-chloro derivatives give some promise. The inhibitory activity of cyclocytidine vs DNA and RNA synthesis approaches the activity of cancerostatic antibotics.