Author:
Pačes Ondřej,Točík Zdeněk,Rosenberg Ivan
Abstract
Synthesis of a novel cyanoethyl-type linker suitable for the solid-phase synthesis of oligodeoxynucleotides possessing terminal 3'-phosphate group is described. Since the linker is a 2-substituted 2-cyanoethanol, the release of the synthesized oligonucleotide from the solid support is accomplished by β-elimination in the ammonia deprotection step.
Publisher
Institute of Organic Chemistry & Biochemistry
Cited by
2 articles.
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