Determination of the Serum Unbound Fraction of Tadalafil in Children with Protein-Losing Enteropathy and Its Specific Binding to Human Serum Proteins in Vitro

Author:

Shigetomi Nanami1,Kamiya Kenta1,Takamori Toru1,Yoshimura Naoki1,Ozawa Sayaka1,Hirono Keiichi1,Ichida Fukiko1,Taguchi Masato1

Affiliation:

1. Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference23 articles.

1. 1) Mertens L, Hagler DJ, Sauer U, Somerville J, Gewillig M. Protein-losing enteropathy after the Fontan operation: an international multicenter study. J. Thorac. Cardiovasc. Surg., 115, 1063–1073 (1998).

2. 2) Feldt RH, Driscoll DJ, Offord KP, Cha RH, Perrault J, Schaff HV, Puga FJ, Danielson GK. Protein-losing enteropathy after Fontan operation. J. Thorac. Cardiovasc. Surg., 112, 672–680 (1996).

3. 3) Jayakumar KA, Addonizio LJ, Kichuk-Chrisant MR, Galantowicz ME, Lamour JM, Quaegebeur JM, Hsu DT. Cardiac transplantation after the Fontan or Glenn procedure. J. Am. Coll. Cardiol., 44, 2065–2072 (2004).

4. 4) Strober W, Wochner RD, Carbone PP, Waldmann TA. Intestinal lymphangiectasia: a protein-losing enteropathy with hypogammaglobulinemia, lymphocytopenia and impaired homograft rejection. J. Clin. Invest., 46, 1643–1656 (1967).

5. 5) Gugler R, Shoeman DW, Huffman DH, Cohlmia JB, Azarnoff DL. Pharmacokinetics of drugs in patients with the nephrotic syndrome. J. Clin. Invest., 55, 1182–1189 (1975).

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