A Reactive Metabolite of Clozapine Induces Hematopoietic Toxicity in HL-60 Cells Undergoing Granulocytic Differentiation through Its Effect on Glutathione Metabolism-Reference-Cited by-同舟云学术

A Reactive Metabolite of Clozapine Induces Hematopoietic Toxicity in HL-60 Cells Undergoing Granulocytic Differentiation through Its Effect on Glutathione Metabolism

Published:2022-09-01 Issue:9 Volume:45 Page:1232-1237
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biological & Pharmaceutical Bulletin

Author:

Torii-Goto Aya¹,Yoshimi Akira²,Tashiro Yuko¹,Ukigai Mako¹,Matsumoto Aoi¹,Ozaki Norio²,Noda Yukihiro¹

Affiliation:

1. Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University

2. Department of Psychiatry, Nagoya University Graduate School of Medicine

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/45/9/45_b22-00045/_pdf

Reference36 articles.

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3. 3) Atkin K, Kendall F, Gould D, Freeman H, Lieberman J, O’Sullivan D. Neutropenia and agranulocytosis in patients receiving clozapine in the U.K. and Ireland. Br. J. Psychiatry, 169, 483–488 (1996).

4. 4) Regen F, Herzog I, Hahn E, Ruehl C, Le Bret N, Dettling M, Heuser I, Hellmann-Regen J. Clozapine-induced agranulocytosis: evidence for an immune-mediated mechanism from a patient-specific in-vitro approach. Toxicol. Appl. Pharmacol., 316, 10–16 (2017).

5. 5) Alvir JM, Lieberman JA, Safferman AZ, Schwimmer JL, Schaaf JA. Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N. Engl. J. Med., 329, 162–167 (1993).

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