Fluorinated Kavalactone Inhibited RANKL-Induced Osteoclast Differentiation of RAW264 Cells

Author:

Kumagai Momochika123,Nishikawa Keisuke3,Mishima Takashi2,Yoshida Izumi2,Ide Masahiro2,Watanabe Akio4,Fujita Kazuhiro2,Morimoto Yoshiki3

Affiliation:

1. Faculty of Fisheries, Kagoshima University

2. Japan Food Research Laboratories

3. Department of Chemistry, Graduate School of Science, Osaka City University

4. Research Institute for Biological Functions, Chubu University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference21 articles.

1. 1) Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: Now and the future. Lancet, 377, 1276–1287 (2011).

2. 2) Rodan GA, Martin TJ. Therapeutic approaches to bone diseases. Science, 289, 1508–1514 (2000).

3. 3) Kato H, Kai A, Kawabata T, Sunderhaus JD, McAfoos TJ, Finefield JM, Sugimoto Y, Williams RM, Tsukamoto S. Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts. Bioorg. Med. Chem. Lett., 27, 4975–4978 (2017).

4. 4) Kaneda T, Yoshida H, Nakajima Y, Toishi M, Nugroho AE, Morita H. Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity. Bioorg. Med. Chem. Lett., 26, 1760–1761 (2016).

5. 5) Lee CC, Liu FL, Chen CL, Chen TC, Liu FC, Ahmed Ali AA, Chang DM, Huang HS. Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones. Bioorg. Med. Chem., 23, 4522–4532 (2015).

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