Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels

Author:

Yasuda Daisuke1,Hiraoka Yoshinori1,Ohno Mikiko2,Nishi Kiyoto3,Iwasaki Hirotaka2,Kita Toru4,Nishi Eiichiro2,Kume Noriaki1

Affiliation:

1. Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

2. Department of Pharmacology, Shiga University of Medical Sciences

3. Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

4. Kobe City College of Nursing

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference37 articles.

1. 1) Wang N, Fulcher J, Abeysuriya N, Park L, Kumar S, Di Tanna GL, Wilcox I, Keech A, Rodgers A, Lal S. Intensive LDL cholesterol-lowering treatment beyond current recommendations for the prevention of major vascular events: a systematic review and meta-analysis of randomised trials including 327037 participants. Lancet Diabetes Endocrinol., 8, 36–49 (2020).

2. 2) Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, Bhala N, Peto R, Barnes EH, Keech A, Simes J, Collins R. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170000 participants in 26 randomised trials. Lancet, 376, 1670–1681 (2010).

3. 3) Shimizu R, Torii H, Yasuda D, Hiraoka Y, Kitada T, Hashida T, Yoshimoto A, Kita T, Kume N. Serum lipid goal attainment in chronic kidney disease (CKD) patients under the Japan Atherosclerosis Society (JAS) 2012 guidelines: a single-center study. J. Atheroscler. Thromb., 22, 949–957 (2015).

4. 4) Shimizu R, Torii H, Yasuda D, Hiraoka Y, Furukawa Y, Yoshimoto A, Iwakura T, Matsuoka N, Tomii K, Kohara N, Hashida T, Kume N. Comparison of serum lipid management between elderly and non-elderly patients with and without coronary heart disease (CHD). Prev. Med. Rep., 4, 192–198 (2016).

5. 5) Goldstein JL, Kita T, Brown MS. Defective lipoprotein receptors and atherosclerosis. Lessons from an animal counterpart of familial hypercholesterolemia. N. Engl. J. Med., 309, 288–296 (1983).

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