Synthesis and Evaluation of Biological Properties of 2-Amino-thiazole-4-carboxamides: Amide Linkage Analogues of Pretubulysin-Reference-Cited by-同舟云学术

Synthesis and Evaluation of Biological Properties of 2-Amino-thiazole-4-carboxamides: Amide Linkage Analogues of Pretubulysin

Published:2020-08-01 Issue:8 Volume:43 Page:1154-1158
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Ouyang Ben¹,Wang Linan¹,Qi Junhui¹,Fan Meixia¹,Wang Haolin¹,Yao Lei¹

Affiliation:

1. School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/43/8/43_b20-00278/_pdf

Reference21 articles.

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2. 2) Steinmetz H, Glaser N, Herdtweck E, Sasse F, Reichenbach H, Höfle G. Isolation, crystal and solution structure determination, and biosynthesis of tubulysins-powerful inhibitors of tubulin polymerization from Myxobacteria. Angew. Chem., 116, 4996–5000 (2004).

3. 3) Nicolaou KC, Erande RD, Yin J, Vourloumis D, Aujay M, Sandoval J, Munneke S, Gavrilyuk J. Improved total synthesis of tubulysins and design, synthesis, and biological evaluation of new tubulysins with highly potent cytotoxicities against cancer cells as potential payloads for antibody-drug conjugates. J. Am. Chem. Soc., 140, 3690–3711 (2018).

4. 4) Nicolaou KC, Yin J, Mandal D, Erande RD, Klahn P, Jin M, Aujay M, Sandoval J, Gavrilyuk J, Vourloumis D. Total synthesis and biological evaluation of natural and designed tubulysins. J. Am. Chem. Soc., 138, 1698–1708 (2016).

5. 5) Braig S, Wiedmann RM, Liebl J, Singer M, Kubisch R, Schreiner L, Abhari BA, Wagner E, Kazmaier U, Fulda S, Vollmar AM. Pretubulysin: a new option for the treatment of metastatic cancer. Cell Death Dis., 5, e1001 (2014).

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