Preparation of New Nitrogen-Bridged Heterocycles. 54. Increased Arene-Arene Interactions of 3-(Bicyclic and Tricyclic Arylmethylthio)thieno [3,4-b] indolizine Derivatives

Author:

Kakehi Akikazu1,Suga Hiroyuki1,Kako Tomonao1,Fujii Tsuneo2,Tanaka Nobuaki2,Kobayashi Tomoshige3

Affiliation:

1. Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University

2. Department of Environmental Science and Technology, Faculty of Engineering, Shinshu University

3. Faculty of Science, Shinshu University

Publisher

Pharmaceutical Society of Japan

Subject

Drug Discovery,General Chemistry,General Medicine

Reference11 articles.

1. Preparation of New Nitrogen-Bridged Heterocycles. 53. Syntheses of 3-(Benzylthio)thieno[3,4-b]indolizine Derivatives and Their Intramolecular Arene-Arene Interactions.

2. A Through-Space Interaction of 3-Benzylthiothieno[3,4-b]indolizine Derivatives Combined by a Highly Flexible Spacer

3. Preparation of new nitrogen-bridged heterocycles. XXIV. Syntheses and reactions of pyrazolo(1,5-a)pyridine-2-thiols. (2).

4. Preparation of New Nitrogen-Bridged Heterocycles. XXXIII. A New Preparative Method for Thieno(3,2-a)indolizines.

5. 5) These 1H-NMR spectra (CDCl3, 300 MHz) are as follows: 2a, δ: 5.02 (2H, s), 7.39 (1H, q, J=7.1, 8.3 Hz), 7.49 (1H, br d, J=7.1 Hz), 7.50 (1H, m), 7.57 (1H, m), 7.82 (1H, br d, J=8.3 Hz), 7.86 (1H, d, J=7.3 Hz), 8.12 (1H, d, J=8.8 Hz); 2b, 2.56 (3H, s), 5.04 (2H, s), 7.28 (1H, d, J=8.4 Hz), 7.42 (1H, m), 7.54 (1H, m), 7.71 (1H, d, J=8.2 Hz), 7.79 (1H, br d, J=8.1 Hz), 8.06 (1H, d, J=8.6 Hz); 2c, 4.64 (2H, s), 7.44—7.52 (3H, m), 7.76—7.84 (4H, m); 2d, 5.55 (2H, s), 7.46 (2H, m), 7.57 (2H, m), 7.97 (2H, br d, J=8.4 Hz), 8.26 (2H, d, J=9.0 Hz), 8.42 (1H, s).

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