Hydrolytic Cleavage of Pyroglutamyl-peptide Bond. V. Selective Removal of Pyroglutamic Acid from Biologically Active Pyroglutamylpeptides in High Concentrations of Aqueous Methanesulfonic Acid-Reference-Cited by-同舟云学术

Hydrolytic Cleavage of Pyroglutamyl-peptide Bond. V. Selective Removal of Pyroglutamic Acid from Biologically Active Pyroglutamylpeptides in High Concentrations of Aqueous Methanesulfonic Acid

Published:2006 Issue:6 Volume:54 Page:827-831
ISSN:0009-2363
Container-title:Chemical and Pharmaceutical Bulletin
language:en
Short-container-title:CHEMICAL & PHARMACEUTICAL BULLETIN

Author:

Kobayashi Junko¹,Ohki Kazuhiro¹,Okimura Keiko¹,Hashimoto Tadashi¹,Sakura Naoki¹

Affiliation:

1. Faculty of Pharmaceutical Sciences, Hokuriku University

Publisher

Pharmaceutical Society of Japan

Subject

Drug Discovery,General Chemistry,General Medicine

Link

http://www.jstage.jst.go.jp/article/cpb/54/6/54_6_827/_pdf

Reference18 articles.

1. Hydrolytic Cleavage of Pyroglutamyl-Peptide Bond. I. The Susceptibility of Pyroglutamyl-Peptide Bond to Dilute Hydrochloric Acid.

2. Hydrolytic Cleavage of Pyroglutamyl-Peptide Bond. II. Effects of Amino Acid Residue Neighboring the pGlu Moiety.

3. Highly Selective Cleavage of Pyroglutamyl-Peptide Bond in Concentrated Hydrochloric Acid.

4. Hydrolytic Cleavage of Pyroglutamyl-Peptide Bond. III. A Highly Selective Cleavage in 70% Methanesulfonic Acid.

5. Hydrolytic Cleavage of Pyroglutamyl-Peptide Bond. IV. Highly Selective Cleavage of Thyrotropin Releasing Hormone (TRH) in Aqueous Methanesulfonic Acid.

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