Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood

Author:

Ozawa Hitomi1,Imaizumi Atsushi2,Sumi Yoshihiko1,Hashimoto Tadashi2,Kanai Masashi3,Makino Yuji4,Tsuda Takanori5,Takahashi Nobuaki6,Kakeya Hideaki6

Affiliation:

1. Theravalues Corp.

2. TheraBioPharma Inc.

3. Department of Clinical Oncology, Kyoto University Hospital Cancer Center

4. Faculty of Pharmacy, Musashino University

5. College of Bioscience and Biotechnology, Chubu University

6. Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference50 articles.

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2. 2) Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern. Med. Rev., 14, 141–153 (2009).

3. 3) Sugiyama Y, Kawakishi S, Osawa T. Involvement of the beta-diketone moiety in the antioxidative mechanism of tetrahydrocurcumin. Biochem. Pharmacol., 52, 519–525 (1996).

4. 4) Wright JS. Predicting the antioxidant activity of curcumin and curcuminoids. J. Mol. Struct. THEOCHEM, 591, 207–217 (2002).

5. 5) Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res., 23 (1A), 363–398 (2003).

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