The Aldosterone Receptor Antagonist Eplerenone Inhibits Isoproterenol-Induced Collagen-I and 11β-HSD1 Expression in Rat Cardiac Fibroblasts and the Left Ventricle
Author:
Affiliation:
1. Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/40/10/40_b17-00291/_pdf
Reference37 articles.
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3. 3) Swedberg K, Eneroth P, Kjekshus J, Wilhelmsen L. Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group. Circulation, 82, 1730–1736 (1990).
4. 4) Hori Y, Yoshioka K, Kanai K, Hoshi F, Itoh N, Higuchi S-I. Spironolactone decreases isoproterenol-induced ventricular fibrosis and matrix metalloproteinase-2 in rats. Biol. Pharm. Bull., 34, 61–65 (2011).
5. 5) Qin W, Rudolph AE, Bond BR, Rocha R, Blomme EA, Goellner JJ, Funder JW, McMahon EG. Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure. Circ. Res., 93, 69–76 (2003).
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