Pharmacokinetics and Metabolism of Streptochlorin and Its Synthetic Derivative, 5-Hydroxy-2′-isobutyl Streptochlorin, in Mice

Author:

Zhou Yuanyuan1,Choi Yeon Jung2,Kim Eunyeong1,Oh Mun Hwan1,Shin Hee Jae3,Kim Sang Kyum2,Lee Kiho14

Affiliation:

1. College of Pharmacy, Korea University

2. College of Pharmacy, Chungnam National University

3. Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology (KIOST)

4. Biomedical Research Center, Korea University Guro Hospital

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference48 articles.

1. 1) Huyck TK, Gradishar W, Manuguid F, Kirkpatrick P. Eribulin mesylate. Nat. Rev. Drug Discov., 10, 173–174 (2011).

2. 2) Molinski TF, Dalisay DS, Lievens SL, Saludes JP. Drug development from marine natural products. Nat. Rev. Drug Discov., 8, 69–85 (2009).

3. 3) Montaser R, Luesch H. Marine natural products: a new wave of drugs? Future Med. Chem., 3, 1475–1489 (2011).

4. 4) Watabe HAS, Yoshida J. A new antibiotic SF2583A, 4-chloro-5(3′-indolyl)oxazole, produced by Streptomyces. Scientific Reports of Meji Seika Kaisha, 1988, 55–62 (1988).

5. 5) Choi IK, Shin HJ, Lee HS, Kwon HJ. Streptochlorin, a marine natural product, inhibits NF-κB activation and suppresses angiogenesis in vitro. J. Microbiol. Biotechnol., 17, 1338–1343 (2007).

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