Characterization of β-Estradiol 3-Glucuronidation in Rat Brain

Author:

Asai Yuki1,Sakakibara Yukiko1,Onouchi Haruka1,Nadai Masayuki1,Katoh Miki1

Affiliation:

1. Department of Pharmaceutics, Faculty of Pharmacy, Meijo University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference36 articles.

1. 1) Itäaho K, Mackenzie PI, Ikushiro S, Miners JO, Finel M. The configuration of the 17-hydroxy group variably influences the glucuronidation of β-estradiol and epiestradiol by human UDP-glucuronosyltransferases. Drug Metab. Dispos., 36, 2307–2315 (2008).

2. 2) Krishnaswamy S, Hao Q, Von Moltke LL, Greenblatt DJ, Court MH. Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6. Drug Metab. Dispos., 32, 862–869 (2004).

3. 3) Itäaho K, Court MH, Uutela P, Kostiainen R, Radominska-Pandya A, Finel M. Dopamine is a low-affinity and high-specificity substrate for the human UDP-glucuronosyltransferase 1A10. Drug Metab. Dispos., 37, 768–775 (2009).

4. 4) Nakamura A, Nakajima M, Yamanaka H, Fujiwara R, Yokoi T. Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. Drug Metab. Dispos., 36, 1461–1464 (2008).

5. 5) Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, Manns MP. Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J. Biol. Chem., 275, 36164–36171 (2000).

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