Qualification of <i>In Vitro</i> Dissolution Absorption System 2 (IDAS2) with Caco-2 and MDCK Cell Monolayers: Dose Sensitivity Study Using BCS Class I and III Drugs
Author:
Affiliation:
1. Pharmaron (Exton) Lab Services LLC (Absorption Systems LLC)
Publisher
Pharmaceutical Society of Japan
Link
https://www.jstage.jst.go.jp/article/bpb/47/6/47_b24-00150/_pdf
Reference16 articles.
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2. 2) Silchenko S, Nessah N, Li J, Li L, Huang Y, Owen A, Hidalgo I. In vitro dissolution absorption system (IDAS2): use for the prediction of food viscosity effects on drug dissolution and absorption from oral solid dosage forms. Eur. J. Pharm. Sci., 143, 105164 (2020).
3. 3) Li J, Bukhtiyarov Y, Spivey N, Force C, Hidalgo C, Huang Y, Owen A, Hidalgo I. In vitro and in vivo assessment of the potential of supersaturation to enhance the absorption of poorly soluble basic drugs. J. Pharm. Innov., 15, 591–602 (2020).
4. 4) Li J, Spivey N, Silchenko S, Gonzalez-Alvarez I, Bermejo M, Hidalgo I. A differential equation based modelling approach to predict supersaturation and in vivo absorption from in vitro dissolution-absorption system (idas2) data. Eur. J. Pharm. Biopharm., 165, 1–12 (2021).
5. 5) Kataoka M, Masaoka Y, Yamazaki Y, Sakane T, Sezaki H, Yamashita S. In vitro system to evaluate oral absorption of poorly water-soluble drugs: simultaneous analysis on dissolution and permeation of drugs. Pharm. Res., 20, 1674–1680 (2003).
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