Efficacy and Safety of Vonoprazan-Based Quadruple Therapy for the Eradication of <i>Helicobacter pylori</i> in Patients with Peptic Ulcers: A Pooled Analysis of Two Randomized, Double-Blind, Double-Dummy, Phase 3 Trials

Author:

Hou Xiaohua1,Wang Jiangbin2,Du Qin3,Tian Dean4,Hu Naizhong5,Liu Deliang6,Zhou Fang7,Xie Li7,Gu Liqun8,Kudou Kentarou7,Zhang Shutian9

Affiliation:

1. Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

2. Department of Gastroenterology, China-Japan Union Hospital, Jilin University

3. Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine

4. Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

5. Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University

6. Department of Gastroenterology, The Second Xiangya Hospital of Central South University

7. Takeda Pharmaceutical Company Ltd.

8. Takeda Development Center Asia

9. Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University

Publisher

Pharmaceutical Society of Japan

Reference49 articles.

1. 1) Fashner J, Gitu AC. Diagnosis and treatment of peptic ulcer disease and H. pylori infection. Am. Fam. Physician, 91, 236–242 (2015). ‹https://pubmed.ncbi.nlm.nih.gov/25955624/›

2. 2) Ramakrishnan K, Salinas RC. Peptic ulcer disease. Am. Fam. Physician, 76, 1005–1012 (2007). ‹https://pubmed.ncbi.nlm.nih.gov/17956071/›

3. 3) Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet, 323, 1311–1315 (1984).

4. 4) Narayanan M, Reddy KM, Marsicano E. Peptic ulcer disease and Helicobacter pylori infection. Mo. Med., 115, 219–224 (2018).

5. 5) Ford AC, Gurusamy KS, Delaney B, Forman D, Moayyedi P. Eradication therapy for peptic ulcer disease in Helicobacter pylori-positive people. Cochrane Database Syst. Rev., 2016, CD003840 (2016).

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