Effects of Repeated Morphine Treatment on the Antinociceptive Effects, Intestinal Absorption, and Efflux from Intestinal Epithelial Cells of Morphine-Reference-Cited by-同舟云学术

Effects of Repeated Morphine Treatment on the Antinociceptive Effects, Intestinal Absorption, and Efflux from Intestinal Epithelial Cells of Morphine

Published:2009 Issue:9 Volume:32 Page:1571-1575
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Okura Takashi¹,Ozawa Tadahiro¹,Ibe Michiko¹,Taki Yuko¹,Kimura Midori¹,Kagawa Yoshiyuki¹,Kato Yoshihisa¹,Yamada Shizuo¹

Affiliation:

1. Department of Pharmacokinetics, Pharmacodynamics, Global Center of Excellence (COE) and Clinical Pharmaceutics, University of Shizuoka School of Pharmaceutical Sciences

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

http://www.jstage.jst.go.jp/article/bpb/32/9/32_9_1571/_pdf

Reference24 articles.

1. 1) Present address: Department of Drug Disposition and Pharmacokinetics, Teikyo University School of Pharmaceutical Sciences; 1091–1 Suarashi Sagamiko, Sagamihara, Kanagawa 229–0195, Japan.

2. 2) Present address: Faculty of Pharmaceutical Sciences of Kagawa Campus, Tokushima Bunri University; Kagawa 769–2193, Japan.

3. Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine

4. Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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