Detection of EBV and CMV coinfection among patients under hemodialysis

Abstract

Background: CMV and EBV infections are a common cause of complications in patients with a variety of chronic diseases, and they are one of the most significant factors preventing patients from completing their treatment successfully. Aim of the study: The study's goal was to determine the frequency of EBV and CMV infections in patients receiving hemodialysis and how that frequency correlated with serum IL-6 levels. Patients and Methods: A cross sectional study was carried out in Kirkuk city from 15th of January 2021 to 15th of November 2021. A total of 87 hemodialysis patients and 33 healthy control group whose ages were between 30-75 years old. These patients admitted to Kirkuk General Hospital. An interview was carried out with these patients using questionnaire form designed by the investigator.   Four ml of blood was collected from each person enrolled in this study for detection of specific EBV, and CMV IgM antibodies and Interleukin-6 by using ELISA technique.Results: The study showed that the highest rate of EBV-IgM Abs was occurred in hemodialysis patients (43.68%) comparing with the control group(9.09%), P<0.01. CMV –IgM was found 47.13% of HD patients and 21.21% of the control group, P<0.01.