Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance
Author:
Publisher
Informa Healthcare
Subject
Pharmacology,Toxicology,General Medicine
Link
http://www.tandfonline.com/doi/pdf/10.1517/17425255.2010.530655
Reference30 articles.
1. The significance of phase II (conjugation) reactions in drug disposition and toxicity
2. The Role of Metabolites of Antidepressants in the Treatment of Depression
3. Biochemical Basis for Deficient Paracetamol Glucuronidation in Cats: an Interspecies Comparison of Enzyme Constraint in Liver Microsomes
4. Molecular basis for deficient acetaminophen glucuronidation in cats
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