Pharmacogenomics in the treatment of narcolepsy-Reference-Cited by-同舟云学术

Pharmacogenomics in the treatment of narcolepsy

Published:2003-01-01 Issue:1 Volume:4 Page:23-33
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Tafti Mehdi¹,Dauvilliers Yves²

Affiliation:

1. Biochemistry and Genetics Unit, Department of Psychiatry, Geneva University Hospitals, 2 Chemin du Petit-Bel-Air, CH-1225 Chêne-Bourg, Switzerland. mehdi.tafti@medecine.unige.ch

2. Neurologie B, Hôpital Gui-de-Chauliac, Montpellier, France

Abstract

Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness and cataplexy. Available treatments of narcolepsy include stimulants and antidepressants but the recent discovery of orexin/hypocretin deficiency in narcolepsy opens up new perspectives. Narcolepsy is a complex disorder involving genetic, immune and environmental factors. Although only a strong association is found with the HLA DQB1*0602 gene, other genetic susceptibility factors might be involved. Among these, the functional polymorphism of the catechol-O-methyltransferase (COMT) gene is critically involved in the severity of narcolepsy and in the response to the stimulant modafinil. Other pharmacogenetic targets include the orexinergic, noradrenergic and possibly the serotonergic pathways.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.1517/phgs.4.1.23.22590

Reference76 articles.

1. Guilleminault C, Dement WC, Passouant P: Narcolepsy. In: Advances in Sleep Research Vol. 3. Spectrum, New York (1976).

2. The International Classification of Sleep Disorders Diagnostic and Coding Manual. Allen Press, Inc. Laurence KS (1990).

3. Jouvet M: The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle. Ergeb. Physiol. (1972) 64, 166-307.

4. Role of adenosine in behavioral state modulation: a microdialysis study in the freely moving cat

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pharmacological options for narcolepsy: are they the way forward?;Expert Review of Neurotherapeutics;2023-08-29

2. Pharmacogenomic Biomarkers;Biomarkers in Medicine;2022-08-30

3. Catechol-O-methyltransferase, dopamine, and sleep-wake regulation;Sleep Medicine Reviews;2015-08

4. Risk Factors for Hypersomnias;Encyclopedia of Sleep;2013

5. Risk factors for hypersomnias;Encyclopedia of Sleep and Circadian Rhythms;2013